Disney’s “Alice in Wonderland” was the biggest ever for a winter release to top the domestic box office with an estimated $116.3 million, as the book-based fantasy popped through the 3D looking glasses and into the history books.
The twelve estimated top producing motion pictures for the weekend, per data collected as of Sunday, March 7, 2010 include:
| Rank | Title | Distributor | Weekend Gross | Cume | Locations |
| 1 | Alice In Wonderland | Disney | $116,300,000 | $116,300,000 | 3728 |
| 2 | Brooklyn’s Finest | Overture Films | $13,500,000 | $13,500,000 | 1936 |
| 3 | Shutter Island | Paramount | $13,300,000 | $95,824,594 | 3178 |
| 4 | Cop Out | Warner Bros. | $9,145,000 | $32,360,299 | 3150 |
| 5 | Avatar | 20th Century Fox | $7,700,000 | $720,189,342 | 2163 |
| 6 | The Crazies | Overture Films | $7,016,000 | $27,409,313 | 2479 |
| 7 | Percy Jackson & The Olympians: Lightning | 20th Century Fox | $5,100,000 | $78,033,126 | 2994 |
| 8 | Valentine’s Day | Warner Bros. | $4,270,000 | $106,419,760 | 3040 |
| 9 | Crazy Heart | Fox Searchlight | $3,350,000 | $29,569,411 | 1274 |
| 10 | Dear John | Sony | $2,850,000 | $76,694,007 | 2496 |
| 11 | Tooth Fairy | 20th Century Fox | $1,675,000 | $56,230,644 | 1734 |
| 12 | The Wolfman | Universal | $1,600,375 | $60,409,860 | 1829 |
